报告题目：Mesoporous Silica Nanoparticles in Medical Imaging and Therapeutic Delivery
报告人： 黄文彦（美国加州大学洛杉矶分校 博士后）
报告时间：2016年9月8日下午15：00
报告地点：理学院报告厅
报告简介：The development and use of nanotechnology towards theranostics (all-in-one disease diagnostics and therapeutic delivery) have been increasing in popularity in recent years, in particular the use of high capacity of nanomaterials to transport both imaging and therapeutic agents into pathological tissues or abnormal cells. In this work, biocompatible mesoporous silica nanoparticles (MSNs) that can be reliably endocytosed by cells are employed in the investigation of novel cancer treatment and magnetic resonance imaging (MRI). One of the principal aims is to develop T1 contrast nanoparticles not only with extraordinarily high MRI contrast characteristics, but also tunability through surface chemistry and functional protein conjugation. In coupling paramagnetic Gd3+-centers to MSNs, one can effectively marry the advantages afforded by increased molecular bulk with those engendered by confined water environment inside the porous network. The MSNs synthesized in this work are used not only in diagnostic imaging but also in the delivery of therapeutic agents for cancer therapy. The agents can be chemically conjugated on the nanoparticles where their retention on nanoparticles, as opposed to being released, plays an important role in the effectiveness of cancer treatment that is achieved by triggering programmed cell death (apoptosis) in this work. In addition to these application-oriented studies, molecular dynamics of dissolved molecules in the fluids inside the pores of MSNs are also investigated by calculating rotational correlation times from spin-lattice relaxation measured using solid-state NMR.
报告人简介：黃文彥博士于2006 毕业于台湾大学化学系，并于2013 年于英国牛津大学获得博士学位 (指导教授: Prof. Jason Davis)，且有将近两年在美国加州大学洛杉矶分校，从事博士后研究工作(指导教授: Prof. Jeffrey Zink)。他在博士研究期间，主要研究二氧化硅纳米材料的表面化学及其与医疗上的应用，也探讨以聚合物及生物分子修饰纳米材料的课题。此外，他也研究提高市场MRI 造影剂之对比度的方法，及开发能借由对比度变化來辨识蛋白质存在与否的MRI造影剂。开发设计上述这些材料除需化学合成的技术也需具备相关的物理知识，尤其是了解分子与纳米尺度的运动行为。因此他特別在美国博士后研究期间，使用固态核磁共振去探讨分子与二氧化硅孔洞间的运动，也找出分子运动与包裹其与纳米球表面化学的关系。
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注：本次讲座纳入生物系继续教育课程。
理学院
2016年9月5日
